Sensitive Molecular Diagnostics for Cutaneous Leishmaniasis
نویسندگان
چکیده
منابع مشابه
Sensitive Molecular Diagnostics for Cutaneous Leishmaniasis
BACKGROUND Rapid diagnosis of cutaneous leishmaniasis (CL) and identification of Leishmania species is highly important for the disease management. In Israel, CL is caused mainly by Leishmania major and Leishmania tropica species. METHODS We established an easy to handle point of care lesion-swabbing, combined with a highly sensitive multiplex real time PCR (multiplex qPCR) for accurate and r...
متن کاملA sensitive new microculture method for diagnosis of cutaneous leishmaniasis.
A sensitive microcapillary culture method (MCM) was developed for rapid diagnosis of cutaneous leishmaniasis (CL). The MCM is superior to the traditional culture method (TCM) as determined by the smaller inoculum size, the higher sensitivity for detection of promastigotes, and the more rapid time for emergence of promastigotes. With lesion amastigote loads from grade III to 0, the positive rate...
متن کاملCutaneous leishmaniasis: advances in disease pathogenesis, diagnostics and therapeutics.
Cutaneous leishmaniasis is one of the most common tropical dermatoses worldwide and is of major public health importance. It is caused by numerous Leishmania protozoa species, which are responsible for its clinical diversity. With changes in vector (sandfly) habitat and increased travel among human populations, its incidence is rising, and in nonendemic countries, including the UK, it is increa...
متن کامل[Cutaneous leishmaniasis].
Cutaneous leishmaniasis is endemic in certain tropical and sub-tropical regions, and is sometimes encountered as an imported disease in Norway. The disease is characterized by chronic and painless, but often disfiguring, ulcers that regress after some months to years, leaving atrophic scars. Diagnosis is established by demonstrating amastigote Leishmania bodies by microscopy of Giemsa-stained s...
متن کاملCutaneous Leishmaniasis
Transforming growthfactor (TGF)-,8 has several downregulatoryfunctions on the immune systenm inhibition ofinterleukin-2 receptor induction, decrease of interferon-yinduced class II antigen expression, inhibition of macrophage activation, as weUl as cytotoxic and lymphokineactivated kilter cell generation. TGF-(8 has also been recognized as an important immunoregulator in murine leishmaniasis, f...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2017
ISSN: 2328-8957
DOI: 10.1093/ofid/ofx037